Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21882641 | 0.80 | MOGAT2 (0.35) | RAB9AESR2HRH3NPC1MOGAT2 | |
| SCHEMBL20173799 | 0.78 | PTGS1 (0.44) | RAB9ANPC1MAPT | |
| SCHEMBL2741634 | 0.72 | OGA (0.43) | RAB9AHRH3ALDH1A1NPC1MOGAT2 | |
| SCHEMBL24671534 | 0.70 | OGA (0.41) | HRH3ALDH1A1MOGAT2KDM4EOGA | |
| SCHEMBL15235297 | 0.69 | MMP2 (0.55) | ALDH1A1 | |
| SCHEMBL21361600 | 0.69 | HRH3 (0.47) | HRH3ALDH1A1KDM4ECHRM2OGA | |
| SCHEMBL20173793 | 0.68 | ALDH1A1 (0.51) | HRH3ALDH1A1KDM4EMAPT | |
| SCHEMBL3879495 | 0.67 | ACACB (0.54) | RAB9AESR2HRH3ALDH1A1NPC1 | |
| SCHEMBL1083820 | 0.67 | MAOA (0.57) | HRH3ALDH1A1KDM4EOGAMAPT | |
| SCHEMBL30561536 | 0.67 | MAOA (0.57) | HRH3ALDH1A1KDM4EOGAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | RAB9A 2852/4885ESR2 1137/4885GAA 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.