Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170674 | 0.87 | KDM4E (0.47) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL4813379 | 0.87 | PARP1 (0.38) | PARP1KDM4EHPGDDHODHPLK4 | |
| SCHEMBL29453826 | 0.87 | KDM4E (0.47) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL29031778 | 0.85 | CCND3 (0.44) | PARP1KDM4E | |
| Phosphine SCHEMBL4726258 | 0.85 | KDM4E (0.46) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL1698316 | 0.85 | PARP1 (0.56) | PARP1DHODHPLK4MAPK13DYRK3 | |
| Ammonia Solution, Strong SCHEMBL6052082 | 0.85 | KDM4E (0.46) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL1761105 | 0.85 | ALDH1A1 (0.37) | PARP1KDM4EHPGDDHODHPLK4 | |
| SCHEMBL9172345 | 0.85 | KDM4E (0.46) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL3840407 | 0.85 | KDM4E (0.46) | PARP1KDM4EHPGDDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117386893-A | Multilayer composite antibacterial PE water supply pipeline and preparation process thereof | 江苏惠升管业集团有限公司 | 2024-01-12 | — | — | CN | claimed |
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | PFIZER INC. (US) | 2019-12-17 | — | — | US | claimed |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2018-05-17 | — | — | US | claimed |
| EP-1777236-B1 | Modified saccharides having improved stability in water for use as a medicament | NOVARTIS AG (CH) | 2016-11-30 | — | — | EP | claimed |
| EP-3066074-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | Pfizer Inc. (US) | 2016-09-14 | — | — | EP | claimed |
| US-20160251389-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2016-09-01 | — | — | US | claimed |
| WO-2015063680-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2015-05-07 | — | — | WO | claimed |
| US-8895516-B2 | Modified saccharides, conjugates thereof, and their manufacture | NOVARTIS AG (CH) | 2014-11-25 | — | — | US | claimed |
| EP-1490409-B1 | MODIFIED SACCHARIDES HAVING IMPROVED STABILITY IN WATER | NOVARTIS VACCINES & DIAGNOSTIC (IT) | 2008-12-31 | — | — | EP | claimed |
| EP-1777236-A1 | Modified saccharides having improved stability in water | Novartis Vaccines and Diagnostics S.r.l. (IT) | 2007-04-25 | — | — | EP | claimed |
| US-20060263390-A1 | Modified saccharides, conjugates thereof, and their manufacture | GLAXOSMITHKLINE BIOLOGICALS SA (BE) | 2006-11-23 | — | — | US | claimed |
| EP-1534342-B1 | MODIFIED SACCHARIDES, CONJUGATES THEREOF, AND THEIR MANUFACTURE | CHIRON SRL (IT) | 2006-03-08 | — | — | EP | claimed |
| EP-1534342-A1 | MODIFIED SACCHARIDES, CONJUGATES THEREOF, AND THEIR MANUFACTURE | Chiron SRL. (IT) | 2005-06-01 | — | — | EP | claimed |
| EP-1490409-A1 | MODIFIED SACCHARIDES HAVING IMPROVED STABILITY IN WATER | Chiron SRL. (IT) | 2004-12-29 | — | — | EP | claimed |
| WO-2004019992-A1 | MODIFIED SACCHARIDES, CONJUGATES THEREOF, AND THEIR MANUFACTURE | CHIRON SRL (IT) | 2004-03-11 | — | — | WO | claimed |
| WO-2003080678-A1 | MODIFIED SACCHARIDES HAVING IMPROVED STABILITY IN WATER | CHIRON SRL (IT) | 2003-10-02 | — | — | WO | claimed |
| US-6403776-B1 | TREATING ANTIBIOTIC COMPOUND WITH NUCLEOPHILE TO CLEAVE PROTECTING GROUP FROM HYDROXYL GROUP | PFIZER INC. | 2002-06-11 | — | — | US | claimed |
| EP-1088828-A2 | Synthesis of carbamate ketolide antibiotics | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | claimed |
| US-11840515-B2 | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c | ACADIA PHARMACEUTICALS INC. (US) | 2023-12-12 | — | — | US | disclosed |
| US-4224439-A | Activated matrix and method of activation | DEVELOPMENT FINANCE CORPORATION OF NEW ZEALAND (NZ) | 1980-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | CALR, CALD1, CYCS | PARP1 2673/4885GPR84 4580/4885KDM4E 4425/4885 |
| US-11840515-B2 | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c | NR3C2, NR2C2, CYP4A22 | PARP1 4009/4885GPR84 1522/4885KDM4E 2641/4885 |
| US-20160251389-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | CALR, CALD1, CYCS | PARP1 2673/4885GPR84 4580/4885KDM4E 4425/4885 |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | CALR, CALD1, CYCS | PARP1 2673/4885GPR84 4580/4885KDM4E 4425/4885 |
| US-20060263390-A1 | Modified saccharides, conjugates thereof, and their manufacture | C9, B3GNT2, OGA | PARP1 2281/4885GPR84 2243/4885KDM4E 2640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.