Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | FABP4 | P15090 | 5/20 | 0.36 |
| ▸ | FABP3 | P05413 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | PPIA | P62937 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21884595 | 0.75 | FABP4 (0.39) | FABP4FABP3HTTFABP5THRA | |
| SCHEMBL27588764 | 0.65 | ESR2 (0.52) | FABP4FABP3HTTFABP5THRA | |
| SCHEMBL1022491 | 0.61 | ALDH1A1 (0.54) | FABP4FABP3HTTFABP5THRA | |
| SCHEMBL7106911 | 0.60 | ESR2 (0.50) | HTTTHRATHRBKDM4EALDH1A1 | |
| SCHEMBL4253909 | 0.60 | CA12 (0.54) | FABP4FABP3HTTKDM4EALDH1A1 | |
| SCHEMBL27505789 | 0.60 | ESR2 (0.50) | HTTTHRATHRBALDH1A1ESR2 | |
| SCHEMBL28999631 | 0.59 | ESR2 (0.48) | HTTTHRATHRBKDM4EALDH1A1 | |
| SCHEMBL28992361 | 0.59 | KMT2A (0.55) | FABP4FABP3FABP5MAP2KDM4E | |
| SCHEMBL9469504 | 0.59 | ALDH1A1 (0.45) | FABP4FABP3HTTFABP5THRA | |
| SCHEMBL11775117 | 0.58 | THRB (0.54) | HTTTHRBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061473-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |