Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.38 |
| ▸ | IDH2 | P48735 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18466077 | 0.86 | ALDH1A1 (0.35) | ALDH1A1GAAL3MBTL1NUDT1IDH2 | |
| SCHEMBL17700712 | 0.86 | MAPK1 (0.48) | ALDH1A1GAAL3MBTL1IDH2MAPK1 | |
| SCHEMBL17700752 | 0.79 | NOS2 (0.54) | ALDH1A1L3MBTL1KDM4ENOS2 | |
| SCHEMBL3809824 | 0.78 | IL1B (0.47) | ALDH1A1GAAL3MBTL1NUDT1IDH2 | |
| SCHEMBL18590247 | 0.77 | KDM4D (0.44) | ALDH1A1GAAL3MBTL1NUDT1MAPK1 | |
| SCHEMBL18466076 | 0.77 | HRH3 (0.40) | ALDH1A1GAAL3MBTL1KDM4ELMNA | |
| SCHEMBL16217431 | 0.77 | KARS1 (0.43) | ALDH1A1NUDT1KDM4ELMNA | |
| SCHEMBL24605491 | 0.76 | MEN1 (0.41) | ALDH1A1NUDT1KDM4EBUB1IRAK4 | |
| SCHEMBL31294545 | 0.76 | IL1B (0.43) | IDH2BUB1IRAK4RIOK2IL1B | |
| SCHEMBL26686808 | 0.76 | IRAK4 (0.35) | NUDT1IDH2BUB1IRAK4NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115388-A1 | IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115388-A1 | IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | ALDH1A1 1862/4885GAA 3660/4885L3MBTL1 1178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.