SCHEMBL218972

SCHEMBL218972

Oc1nc(S)c2nc[nH]c2n1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
CSNK2A2 P19784 1/20 0.32
RAB9A P51151 1/20 0.32
CSNK2B P67870 1/20 0.32
CSNK2A1 P68400 1/20 0.32
DYRK1A Q13627 1/20 0.32
CSNK2A3 Q8NEV1 1/20 0.32
POLB P06746 1/20 0.32
BCL2 P10415 1/20 0.30
MCL1 Q07820 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9154110 0.88
Xanthine SCHEMBL9443796 0.79 MEN1 (0.34) LMNAMEN1KMT2ACSNK2A2RAB9A
Xanthine SCHEMBL918381 0.79 MEN1 (0.34) LMNAMEN1KMT2ACSNK2A2RAB9A
SCHEMBL1275415 0.79 KDM4E (0.31) MEN1KMT2ACSNK2A2RAB9ACSNK2B
Isoguanine SCHEMBL887740 0.76 PARP1 (0.36) LMNAMEN1KMT2ACSNK2A2RAB9A
SCHEMBL218201 0.76 CSNK2A1 (0.37) CSNK2A2CSNK2A1DYRK1A
SCHEMBL16146852 0.76 MEN1 (0.36) MEN1KMT2ACSNK2A2RAB9ACSNK2B
SCHEMBL1371017 0.76 PDPK1 (0.31)
Thioguanine SCHEMBL218891 0.76 PDPK1 (0.37)
SCHEMBL16146330 0.76 CSNK2A1 (0.33) LMNAMEN1KMT2ACSNK2A2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140303112-A1 Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) ENERGENESIS BIOMEDICAL CO., LTD (TW) 2014-10-09 US claimed
US-6369208-B1 INFLUENZA ENDONUCLEASE APATAMER THAT INHIBITS INFLUENZA ENDONUCLEASE AND IS RESISTANT TO CLEAVAGE BY SAID ENZYME MERCK & CO., INC. 2002-04-09 US claimed
JP-3257675-B2 2002-02-18 JP claimed
US-5817635-A RNA MOLECULES WITH CATALYTIC ACTIVITY MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) 1998-10-06 US claimed
EP-0552178-B1 MODIFIED RIBOZYMES MAX PLANCK GESELLSCHAFT (DE) 1997-01-02 EP claimed
EP-0552178-A1 MODIFIED RIBOZYMES. MAX PLANCK GESELLSCHAFT (DE) 1993-07-28 EP claimed
WO-1992007065-A1 MODIFIED RIBOZYMES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 1992-04-30 WO claimed
US-20260056202-A1 USE OF MODIFIED PHAGE FOR CAPTURING AND SUBTYPING OF CANCER CELLS UNIV HONG KONG CHINESE (CN) 2026-02-26 US disclosed
US-12553054-B2 Compositions and methods related to nucleic acid anticoagulants NORTH CAROLINA STATE UNIVERSITY (US) 2026-02-17 US disclosed
US-20260009038-A1 COMPOSITIONS AND METHODS RELATED TO NUCLEIC ACID SENSORS UNIV ARIZONA STATE (US) 2026-01-08 US disclosed
EP-4605550-A2 COMPOSITIONS AND METHODS RELATED TO NUCLEIC ACID SENSORS Arizona Board of Regents on behalf of Arizona State University (US) 2025-08-27 EP disclosed
US-20250188517-A1 COMPOSITIONS AND METHODS RELATED TO NUCLEIC ACID SENSORS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2025-06-12 US disclosed
CN-112955553-B Compositions and methods relating to nucleic acid anticoagulants 北卡罗来纳大学 2025-03-14 CN disclosed
US-5213972-A Production of thymidine and deoxyuridine, intermediates for AZT CHEMGEN CORPORATION (US) 1993-05-25 US disclosed
US-5164390-A Cardiac disorders ORTHO PHARMACEUTICAL CORPORATION (US) 1992-11-17 US disclosed
WO-1992007065-A1 MODIFIED RIBOZYMES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 1992-04-30 WO disclosed
US-5021574-A Cardiotonic agents, antiarrhythmia agents ORTHO PHARMACEUTICAL CORPORATION (US) 1991-06-04 US disclosed
US-4294920-A PEPTIZATION, PROTECTIVE COLLOIDS AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) 1981-10-13 US disclosed
EP-0005200-B1 SILVER HALIDE PHOTOGRAPHIC MATERIAL AND METHOD OF PREPARATION Agfa-Gevaert AG (DE) 1981-04-15 EP disclosed
EP-0005200-A2 Silver halide photographic material and method of preparation Agfa-Gevaert AG (DE) 1979-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140303112-A1 Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) PRKAG2, PRKAB2, PRKAG1 LMNA 599/4885MEN1 3276/4885KMT2A 3050/4885
US-20260009038-A1 COMPOSITIONS AND METHODS RELATED TO NUCLEIC ACID SENSORS ADAR, ADA, YARS1 LMNA 527/4885MEN1 4266/4885KMT2A 2402/4885
US-12553054-B2 Compositions and methods related to nucleic acid anticoagulants NSUN2, NSUN3, ADAR LMNA 636/4885MEN1 2083/4885KMT2A 859/4885
US-20260056202-A1 USE OF MODIFIED PHAGE FOR CAPTURING AND SUBTYPING OF CANCER CELLS DNMT3A, SELPLG, TP53 LMNA 727/4885MEN1 3640/4885KMT2A 407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.