Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30087939 | 0.84 | XDH (0.44) | XDHSLC22A12IMPDH2IMPDH1RIPK1 | |
| SCHEMBL28604961 | 0.84 | XDH (0.44) | XDHSLC22A12IMPDH2IMPDH1RIPK1 | |
| SCHEMBL28601707 | 0.77 | XDH (0.46) | XDHSLC22A12IMPDH2IMPDH1RIPK1 | |
| SCHEMBL30088006 | 0.77 | XDH (0.46) | XDHSLC22A12IMPDH2IMPDH1RIPK1 | |
| SCHEMBL21920740 | 0.72 | IMPDH2 (0.44) | XDHSLC22A12IMPDH2IMPDH1RIPK1 | |
| SCHEMBL28603297 | 0.69 | ALDH1A1 (0.40) | XDHSLC22A12IKBKBCHUKESR1 | |
| SCHEMBL30087782 | 0.69 | ALDH1A1 (0.40) | XDHSLC22A12IKBKBCHUKESR1 | |
| SCHEMBL30087787 | 0.69 | ALDH1A1 (0.40) | XDHSLC22A12IKBKBCHUKESR1 | |
| SCHEMBL988243 | 0.69 | IMPDH2 (0.50) | XDHSLC22A12IMPDH2IMPDH1RIPK1 | |
| SCHEMBL21920738 | 0.69 | NR3C1 (0.56) | XDHSLC22A12IMPDH2IMPDH1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |