SCHEMBL21928448

SCHEMBL21928448

Cc1cc(C)cc(-c2ccc3c(c2)c2ccccc2n3-c2cncc(-n3c4ccccc4c4cc(-c5cc(C)cc(C)c5)ccc43)c2-c2ccc(C#N)cc2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 2/20 0.40
SCN10A Q9Y5Y9 2/20 0.36
KCNH2 Q12809 1/20 0.36
CHEK1 O14757 1/20 0.35
AR P10275 3/20 0.35
SCN2A Q99250 1/20 0.35
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
RORC P51449 5/20 0.34
PDE9A O76083 1/20 0.34
PDE1C Q14123 1/20 0.34
MAPK14 Q16539 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
CASP1 P29466 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PIK3CD O00329 1/20 0.33
PIK3CA P42336 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21928450 0.94 SCN10A (0.39) SCN10AKCNH2CHEK1ARSCN2A
SCHEMBL21928596 0.94 CHEK1 (0.40) PTGER4SCN10AKCNH2CHEK1AR
SCHEMBL21929266 0.93 CYP11B2 (0.43) PTGER4CHEK1ARCYP11B1CYP11B2
SCHEMBL21929284 0.92 PTGER4 (0.41) PTGER4SCN10AKCNH2CHEK1AR
SCHEMBL24738590 0.92 ALDH1A3 (0.37) PTGER4KDM4EALDH1A1HPGDHSD17B10
SCHEMBL21928626 0.91 PTGER4 (0.40) PTGER4SCN10AKCNH2CHEK1AR
SCHEMBL21928635 0.91 PTGER4 (0.39) PTGER4CHEK1ARCYP11B1CYP11B2
SCHEMBL21929272 0.90 PTGER4 (0.38) PTGER4CHEK1ARCYP11B2RORC
SCHEMBL21931741 0.90 PTGER4 (0.40) PTGER4CHEK1ARCYP11B1CYP11B2
SCHEMBL21931737 0.90 PTGER4 (0.40) PTGER4CHEK1ARCYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220388960-A1 ORGANIC MOLECULES FOR USE IN LIGHT-EMITTING DEVICES CYNORA GMBH (DE) 2022-12-08 US disclosed
US-20200136054-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2020-04-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200136054-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, OGFR, OR51E2 PTGER4 1018/4885SCN10A 3912/4885KCNH2 1252/4885
US-20220388960-A1 ORGANIC MOLECULES FOR USE IN LIGHT-EMITTING DEVICES ALDH1A2, AOX1, CYBA PTGER4 1294/4885SCN10A 4252/4885KCNH2 1823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.