Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | F9 | P00740 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24783860 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1POLBHPGDCASP1 | |
| SCHEMBL7904187 | 0.79 | CYP3A4 (0.47) | KDM4EALDH1A1POLBHPGDF9 | |
| SCHEMBL22424604 | 0.79 | F9 (0.47) | F9MAPK14F7F3LCK | |
| SCHEMBL7902665 | 0.76 | CA12 (0.50) | KDM4EALDH1A1F9MAPK14LCK | |
| SCHEMBL12012754 | 0.76 | NOS3 (0.39) | KDM4EALDH1A1HPGDHSD17B10F9 | |
| SCHEMBL23380205 | 0.75 | F9 (0.47) | KDM4EALDH1A1HPGDHSD17B10F9 | |
| SCHEMBL9212282 | 0.74 | F9 (0.45) | KDM4EALDH1A1HPGDHSD17B10F9 | |
| SCHEMBL3885375 | 0.73 | ALDH1A1 (0.54) | KDM4EALDH1A1POLBHPGDCASP1 | |
| SCHEMBL25124383 | 0.73 | GRM4 (0.47) | KDM4EALDH1A1POLBHPGDCASP1 | |
| SCHEMBL12545753 | 0.73 | RAB9A (0.56) | KDM4EALDH1A1HPGDHSD17B10F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2770998-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2020-04-29 | — | — | EP | disclosed |