Sugi Predict

Sugi Predict / Compounds / Ethylene Glycol

Ethylene Glycol

Ethylene Glycol

SCHEMBL2193141

NC(=O)CCN1C(=O)C=CC1=O.OCCO.OCCO.OCCO.OCCO

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS1 P23219 7/20 0.47
▸ PTGS2 P35354 7/20 0.47
▸ MGLL Q99685 7/20 0.46
▸ FAAH O00519 3/20 0.46
▸ ALDH1A1 P00352 3/20 0.45
▸ LMNA P02545 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ NPSR1 Q6W5P4 2/20 0.45
▸ HPGD P15428 2/20 0.45
▸ MAPK1 P28482 2/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ HSP90AA1 P07900 1/20 0.45
▸ TLR9 Q9NR96 1/20 0.45
▸ TP53 P04637 1/20 0.45
▸ PKM P14618 1/20 0.45
▸ XBP1 P17861 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ RECQL P46063 1/20 0.45
▸ RAB9A P51151 1/20 0.45
▸ GPR35 Q9HC97 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene Glycol SCHEMBL1082278 1.00 PTGS1 (0.47) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL255340 0.94 MGLL (0.52) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL1704532 0.83 MGLL (0.62) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL31038302 0.82 PTGS1 (0.46) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL22398888 0.82 PTGS1 (0.69) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL14398036 0.81 PTGS1 (0.41) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL19817136 0.80 PTGS1 (0.72) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL28698933 0.80 PTGS1 (0.72) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL30180925 0.80 PTGS1 (0.72) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL1887612 0.80 PTGS1 (0.72) PTGS1PTGS2MGLLFAAHALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2350118-B1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2016-03-30 — — EP disclosed
US-8916693-B2 Monoconjugated chitosans as delivery agents for small interfering nucleic acids NEKTAR THERAPEUTICS (US) 2014-12-23 — — US disclosed
US-8680263-B2 Carbohydrate-based drug delivery polymers and conjugates thereof NEKTAR THERAPEUTICS (US) 2014-03-25 — — US disclosed
US-20120238735-A1 Monoconjugated Chitosans as Delivery Agents for Small Interfering Nucleic Acids NEKTAR THERAPEUTICS (CA) 2012-09-20 — — US disclosed
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2011-07-14 — — US disclosed
WO-2010033240-A2 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2010-03-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF STT3B, STT3A, DDOST PTGS1 4626/4885PTGS2 4681/4885MGLL 885/4885
US-20120238735-A1 Monoconjugated Chitosans as Delivery Agents for Small Interfering Nucleic Acids CHIA, CLTA, CLTC PTGS1 2805/4885PTGS2 3406/4885MGLL 3438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.