SCHEMBL2194879

SCHEMBL2194879

c1ccc(Oc2ccccc2-c2ccccn2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.51
LMNA P02545 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
ADRA1D P25100 1/20 0.47
ADRA1A P35348 1/20 0.47
ADRA1B P35368 1/20 0.47
KDM4E B2RXH2 3/20 0.46
POLB P06746 2/20 0.46
BLM P54132 2/20 0.46
CYP1A2 P05177 1/20 0.46
CCR1 P32246 1/20 0.46
CCR5 P51681 1/20 0.46
CCR8 P51685 1/20 0.46
METAP1 P53582 1/20 0.46
HIF1A Q16665 1/20 0.46
DOHH Q9BU89 1/20 0.46
P4HTM Q9NXG6 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methyl Alcohol SCHEMBL6827620 0.96 GRM5 (0.49) GRM5LMNASMN1; SMN2L3MBTL1ADRA1D
SCHEMBL7196588 0.88 KDM4E (0.54) GRM5LMNASMN1; SMN2L3MBTL1ADRA1D
SCHEMBL6244216 0.85 CA1 (0.57) GRM5LMNASMN1; SMN2L3MBTL1ADRA1D
SCHEMBL5321203 0.82 FFAR1 (0.46) GRM5LMNASMN1; SMN2ADRA1DADRA1A
SCHEMBL22122698 0.81 KDM4E (0.53) GRM5LMNASMN1; SMN2L3MBTL1ADRA1D
SCHEMBL10476160 0.81 NCOA1 (0.46) GRM5LMNAADRA1ANCOA1NCOA3
SCHEMBL28254851 0.81 ADRA1A (0.51) GRM5ADRA1DADRA1AADRA1BPOLB
SCHEMBL27948891 0.80 LMNA (0.46) GRM5LMNASMN1; SMN2L3MBTL1KDM4E
Diphenylether SCHEMBL28242094 0.80 KDM4E (0.67) GRM5LMNASMN1; SMN2L3MBTL1KDM4E
SCHEMBL31039974 0.79 BTK (0.51) GRM5LMNASMN1; SMN2L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102790180-A Transmission organic electroluminescent device with color conversion layer outside OCEANS KING LIGHTING SCIENCE 2012-11-21 CN claimed
CN-102790180-A Transmission organic electroluminescent device with color conversion layer outside OCEANS KING LIGHTING SCIENCE 2012-11-21 CN disclosed
US-8071769-B2 Aromatic monomer- and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-06 US disclosed
US-20110172426-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-07-14 US disclosed
US-20100247435-A1 MEASUREMENT OF NEURAL ACTIVITY ARSTAD ERIK 2010-09-30 US disclosed
US-20100160631-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICHAL COMPANY, LIMITED (JP) 2010-06-24 US disclosed
US-7705528-B2 Aromatic monomer-and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-27 US disclosed
CN-101678127-A Measurement of neural activity HAMMERSMITH IMANET LTD 2010-03-24 CN disclosed
EP-2155260-A1 MEASUREMENT OF NEURAL ACTIVITY Hammersmith Imanet, Ltd (GB) 2010-02-24 EP disclosed
CN-100582114-C Aromatic monomer-and conjugated polymer-metal complexes SUMITOMO CHEMICAL CO 2010-01-20 CN disclosed
WO-2008152109-A1 MEASUREMENT OF NEURAL ACTIVITY HAMMERSMITH IMANET LIMITED (GB) 2008-12-18 WO disclosed
WO-2005016945-A1 AROMATIC MONOMER-AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-24 WO disclosed
US-20050031900-A1 Aromatic monomer-and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100247435-A1 MEASUREMENT OF NEURAL ACTIVITY GAP43, ACHE, BDNF GRM5 34/4885LMNA 1853/4885SMN1; SMN2 121/4885
US-20100160631-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES DDT, TYR, DDC GRM5 2936/4885LMNA 1970/4885SMN1; SMN2 2941/4885
US-20110172426-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES DDT, TYR, DDC GRM5 2936/4885LMNA 1970/4885SMN1; SMN2 2941/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.