Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 7/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1495350 | 0.74 | KDM4E (0.48) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL29509974 | 0.74 | NOS1 (0.48) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL10806951 | 0.74 | NOS1 (0.48) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL460550 | 0.74 | HSP90AA1 (0.40) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL503223 | 0.74 | NOS1 (0.48) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL31414356 | 0.74 | HSP90AA1 (0.40) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL8296672 | 0.74 | RAB9A (0.41) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL22941283 | 0.74 | HSP90AA1 (0.40) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL29626644 | 0.74 | METAP2 (0.44) | NOS1HSP90AA1IDO1CDK2MAPT | |
| SCHEMBL13208472 | 0.74 | TRPA1 (0.40) | NOS1HSP90AA1IDO1CDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| EP-3333157-B1 | VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS | HARBIN ZHENBAO PHARMACEUTICAL CO LTD (CN) | 2020-12-23 | — | — | EP | disclosed |
| WO-2020079652-A1 | KINASE INHIBITORS | Insilico Medicine Hong Kong Limited (CN) | 2020-04-23 | — | — | WO | disclosed |