Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 9/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10124513 | 1.00 | METAP2 (0.44) | METAP2AXLTRPA1TRPM8HSP90AA1 | |
| SCHEMBL13208472 | 0.81 | TRPA1 (0.40) | METAP2TRPA1HSP90AA1IDO1CDK2 | |
| SCHEMBL21951135 | 0.74 | NOS1 (0.48) | METAP2HSP90AA1IDO1CDK2NOS1 | |
| SCHEMBL31414356 | 0.74 | HSP90AA1 (0.40) | METAP2TRPA1HSP90AA1IDO1CDK2 | |
| SCHEMBL460550 | 0.74 | HSP90AA1 (0.40) | METAP2TRPA1HSP90AA1IDO1CDK2 | |
| SCHEMBL30166995 | 0.71 | MAOB (0.36) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL14630014 | 0.71 | MAOB (0.36) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL8296672 | 0.69 | RAB9A (0.41) | METAP2TRPA1HSP90AA1IDO1CDK2 | |
| SCHEMBL503223 | 0.69 | NOS1 (0.48) | METAP2AXLHSP90AA1IDO1CDK2 | |
| SCHEMBL22941283 | 0.69 | HSP90AA1 (0.40) | METAP2HSP90AA1IDO1CDK2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |