Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373603 | 0.83 | HCAR3 (0.38) | ALDH1A1POLBPTGS2MEN1KMT2A | |
| SCHEMBL21960936 | 0.79 | PKM (0.40) | HPGDALDH1A1POLBMEN1KMT2A | |
| SCHEMBL6035336 | 0.78 | ALDH1A1 (0.42) | OPRK1ALDH1A1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL611620 | 0.76 | CA12 (0.41) | ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL29058385 | 0.76 | PSMB8 (0.42) | OPRK1ALDH1A1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL21961452 | 0.76 | ALDH1A1 (0.38) | OPRK1ALDH1A1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL15767938 | 0.75 | POLB (0.34) | ALDH1A1POLBPTGS2MEN1KMT2A | |
| SCHEMBL19284313 | 0.74 | KCNJ6 (0.38) | ALDH1A1ATMSMN1; SMN2NPSR1SLC6A3 | |
| SCHEMBL21964572 | 0.74 | CMKLR1 (0.33) | ALDH1A1POLBPTGS2MEN1KMT2A | |
| SCHEMBL21960356 | 0.73 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |