Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMKLR1 | Q99788 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.31 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373603 | 0.75 | HCAR3 (0.38) | POLBPTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL21960367 | 0.74 | OPRK1 (0.39) | POLBPTGS2PDE7AALDH1A1MEN1 | |
| SCHEMBL15767938 | 0.72 | POLB (0.34) | CMKLR1POLBPTGS2MAPK13MAPK12 | |
| SCHEMBL21960888 | 0.68 | BAZ2B (0.39) | POLBPDE7AALDH1A1MEN1KMT2A | |
| SCHEMBL21960936 | 0.68 | PKM (0.40) | POLBALDH1A1MEN1KMT2A | |
| SCHEMBL21961446 | 0.68 | PTGS2 (0.41) | PTGS2 | |
| SCHEMBL25405989 | 0.62 | CYP4F2 (0.41) | POLBHTTALDH1A1MEN1KMT2A | |
| SCHEMBL31018603 | 0.62 | F2 (0.40) | HTTKCNJ6KCNJ5KCNJ3ALDH1A1 | |
| SCHEMBL31052556 | 0.61 | MAPT (0.47) | KCNJ6KCNJ5KCNJ3ALDH1A1MEN1 | |
| SCHEMBL2053383 | 0.60 | ALDH1A1 (0.34) | POLBALDH1A1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |