Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 11/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.34 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21964588 | 0.82 | HCAR3 (0.40) | L3MBTL1ALDH1A1 | |
| SCHEMBL21960901 | 0.80 | KDM4E (0.41) | L3MBTL3L3MBTL1MAP3K14ALDH1A1NPC1 | |
| SCHEMBL21961452 | 0.78 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL21960397 | 0.77 | JMJD6 (0.37) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21960936 | 0.76 | PKM (0.40) | L3MBTL3L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL21013241 | 0.63 | MEN1 (0.37) | L3MBTL1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21964601 | 0.63 | ALPL (0.49) | ALDH1A1NPC1RAB9AKDM4EHPGD | |
| SCHEMBL25400204 | 0.61 | KCNJ3 (0.45) | ALDH1A1KDM4E | |
| SCHEMBL3060712 | 0.60 | KCNJ6 (0.42) | ALDH1A1KDM4E | |
| SCHEMBL31106627 | 0.60 | CDK4 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |