Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 3/20 | 0.36 |
| ▸ | FPR1 | P21462 | 2/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13718607 | 0.91 | DGAT1 (0.46) | DGAT1MCHR1MEN1KMT2ARXFP1 | |
| SCHEMBL2198200 | 0.90 | MCHR1 (0.36) | MCHR1FPR2BRD4CREBBPCHRNB2 | |
| SCHEMBL2196468 | 0.89 | MCHR1 (0.39) | DGAT1MCHR1FPR2FPR1S1PR5 | |
| SCHEMBL2196467 | 0.89 | MCHR1 (0.39) | DGAT1MCHR1FPR2FPR1S1PR5 | |
| SCHEMBL2197874 | 0.88 | BRD4 (0.38) | DGAT1BRD4CREBBPHTR2AHTR2C | |
| SCHEMBL2197233 | 0.84 | DGAT1 (0.42) | DGAT1BRD4CREBBPKMT2A | |
| SCHEMBL2180267 | 0.82 | MEN1 (0.42) | DGAT1MCHR1MEN1KMT2ARXFP1 | |
| SCHEMBL13719434 | 0.82 | KDM1A (0.44) | DGAT1MCHR1CREBBP | |
| SCHEMBL2279505 | 0.81 | SCN1A (0.39) | MCHR1BRD4CREBBPSCN1ASCN5A | |
| SCHEMBL2181331 | 0.80 | SLC2A1 (0.41) | DGAT1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |