Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 4/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196467 | 1.00 | MCHR1 (0.39) | MCHR1SCN1ASCN5ASCN9AS1PR5 | |
| SCHEMBL2179789 | 0.91 | JAK2 (0.44) | MCHR1DGAT1 | |
| SCHEMBL2179791 | 0.91 | JAK2 (0.44) | MCHR1DGAT1 | |
| SCHEMBL2279505 | 0.90 | SCN1A (0.39) | MCHR1SCN1ASCN5ASCN9ABRD4 | |
| SCHEMBL2197280 | 0.89 | DGAT1 (0.41) | MCHR1SCN1ASCN5ASCN9AS1PR5 | |
| SCHEMBL2197846 | 0.87 | JAK2 (0.38) | S1PR5HTR2AHTR2CHTR2BBRD4 | |
| SCHEMBL2279512 | 0.85 | MCHR1 (0.39) | MCHR1SCN1ASCN5ASCN9ADGAT1 | |
| SCHEMBL2201496 | 0.83 | MGLL (0.40) | DGAT1BRD4CREBBPKDR | |
| SCHEMBL2198200 | 0.81 | MCHR1 (0.36) | MCHR1SCN1ASCN5ASCN9ABRD4 | |
| SCHEMBL13719196 | 0.80 | KDM1A (0.45) | MCHR1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |