Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 5/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | APOB | P04114 | 3/20 | 0.36 |
| ▸ | MTTP | P55157 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196468 | 0.90 | MCHR1 (0.39) | SCN1ASCN5ASCN9AMCHR1BRD4 | |
| SCHEMBL2196467 | 0.90 | MCHR1 (0.39) | SCN1ASCN5ASCN9AMCHR1BRD4 | |
| SCHEMBL2198200 | 0.89 | MCHR1 (0.36) | SCN1ASCN5ASCN9AMCHR1APOB | |
| SCHEMBL2279512 | 0.83 | MCHR1 (0.39) | SCN1ASCN5ASCN9AMCHR1APOB | |
| SCHEMBL13719272 | 0.82 | CRBN (0.39) | — | |
| SCHEMBL2180267 | 0.81 | MEN1 (0.42) | MCHR1JAK2JAK1 | |
| SCHEMBL2179791 | 0.81 | JAK2 (0.44) | MCHR1JAK2JAK1 | |
| SCHEMBL2179789 | 0.81 | JAK2 (0.44) | MCHR1JAK2JAK1 | |
| SCHEMBL2197280 | 0.81 | DGAT1 (0.41) | SCN1ASCN5ASCN9AMCHR1BRD4 | |
| SCHEMBL2197775 | 0.77 | BRD4 (0.35) | BRD4CREBBPMAPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |