Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21979527 | 1.00 | LMNA (0.35) | LMNASMN1; SMN2CYP3A4CYP2D6FFAR2 | |
| SCHEMBL21979525 | 1.00 | LMNA (0.35) | LMNASMN1; SMN2CYP3A4CYP2D6FFAR2 | |
| SCHEMBL29944709 | 0.83 | ABCB1 (0.39) | LMNACYP3A4UTS2RMEN1CYP1A2 | |
| SCHEMBL29944667 | 0.83 | ABCB1 (0.39) | LMNACYP3A4UTS2RMEN1CYP1A2 | |
| SCHEMBL21979510 | 0.75 | CYP26A1 (0.43) | FFAR2UTS2RKMT2ACYP26A1 | |
| SCHEMBL21979526 | 0.75 | CYP26A1 (0.43) | FFAR2UTS2RKMT2ACYP26A1 | |
| SCHEMBL21979511 | 0.75 | CYP26A1 (0.43) | FFAR2UTS2RKMT2ACYP26A1 | |
| SCHEMBL1154778 | 0.75 | AOC3 (0.42) | LMNASMN1; SMN2FFAR2MEN1KMT2A | |
| SCHEMBL5425144 | 0.75 | AOC3 (0.42) | LMNASMN1; SMN2FFAR2MEN1KMT2A | |
| SCHEMBL3972679 | 0.75 | MT-CO2 (0.34) | CYP3A4MEN1CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2022-10-25 | — | — | US | disclosed |
| US-20200165206-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | ROCK1, ROCK2, RHOT2 | LMNA 2071/4885SMN1; SMN2 1627/4885CYP3A4 4857/4885 |
| US-20200165206-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | ROCK1, ROCK2, RHOT2 | LMNA 2071/4885SMN1; SMN2 1627/4885CYP3A4 4857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.