Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606318 | 0.92 | ALDH1A1 (0.36) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL538021 | 0.89 | ALDH1A1 (0.36) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL3193158 | 0.87 | ALDH1A1 (0.35) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| Mercaptopropionic Acid SCHEMBL28353498 | 0.86 | ACE (0.33) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL18289503 | 0.84 | THRB (0.35) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL56622 | 0.83 | THRB (0.37) | ALDH1A1MAPK1HIF1A | |
| SCHEMBL19903041 | 0.83 | THRB (0.33) | ALDH1A1 | |
| SCHEMBL331657 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL330872 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL330799 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116931266-A | Optical structure, preparation method thereof and AR display device | 华为技术有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-110080000-B | Preparation method of spray decontamination high-shape-retention worsted clothes | 江苏阳光集团有限公司 | 2022-05-06 | — | — | CN | disclosed |
| EP-3658595-A1 | METHOD FOR PREPARING A CROSS-LINKED FLUORINATED POLYMER FILM | Arkema France (FR) | 2020-06-03 | — | — | EP | disclosed |