Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328585 | 0.75 | DRD4 (0.51) | DRD4CYP11B2 | |
| SCHEMBL21030280 | 0.67 | GDA (0.33) | ALDH1A1TSHR | |
| SCHEMBL21678829 | 0.67 | DRD2 (0.43) | DRD4CYP11B2ALDH1A1HTR1ADRD2 | |
| SCHEMBL21678165 | 0.66 | CDC7 (0.40) | HTR1ADRD2HTR2A | |
| SCHEMBL20011085 | 0.66 | GDA (0.32) | ALDH1A1TSHR | |
| SCHEMBL22476540 | 0.64 | — | — | |
| SCHEMBL21363443 | 0.63 | SRC (0.38) | — | |
| SCHEMBL8309980 | 0.63 | MAP2K1 (0.37) | ALDH1A1TSHROR51E2 | |
| SCHEMBL2402912 | 0.62 | DRD4 (0.41) | DRD4ALDH1A1TSHR | |
| SCHEMBL13326541 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112424195-B | Fused lactam derivatives | 住友制药株式会社 | 2025-03-25 | — | — | CN | disclosed |
| US-20250084090-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2025-03-13 | — | — | US | disclosed |
| US-12180213-B2 | Substituted pyrazoles showing serotonin 5-HT receptor activity | SUMITOMO PHARMA CO. LTD. (JP) | 2024-12-31 | — | — | US | disclosed |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2023-01-12 | — | — | US | disclosed |
| US-11466007-B2 | Substituted lactams showing serotonin 5-HT receptor activity | Sumitomo Pharma Co., Ltd. (JP) | 2022-10-11 | — | — | US | disclosed |
| EP-3828182-A1 | FUSED RING LACTAM DERIVATIVES | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2021-06-02 | — | — | EP | disclosed |
| CN-112424195-A | Condensed lactam derivatives | 大日本住友制药株式会社 | 2021-02-26 | — | — | CN | disclosed |
| US-10745401-B2 | Condensed lactam derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-18 | — | — | US | disclosed |
| US-10745401-B2 | Condensed lactam derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-18 | — | — | US | disclosed |
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-13 | — | — | US | disclosed |
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-13 | — | — | US | disclosed |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-06-04 | — | — | US | disclosed |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | DRD4 729/4885CYP11B2 536/4885ALDH1A1 858/4885 |
| US-20250084090-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | HTR1A, HTR5A, TPH1 | DRD4 126/4885CYP11B2 1438/4885ALDH1A1 973/4885 |
| US-12180213-B2 | Substituted pyrazoles showing serotonin 5-HT receptor activity | HTR5A, HTR1A, TPH1 | DRD4 197/4885CYP11B2 321/4885ALDH1A1 753/4885 |
| US-10745401-B2 | Condensed lactam derivative | PSEN1, GRIN1, HDAC1 | DRD4 729/4885CYP11B2 536/4885ALDH1A1 858/4885 |
| US-11466007-B2 | Substituted lactams showing serotonin 5-HT receptor activity | HTR1A, HTR5A, TPH1 | DRD4 126/4885CYP11B2 1438/4885ALDH1A1 973/4885 |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | HTR1A, HTR5A, TPH1 | DRD4 126/4885CYP11B2 1438/4885ALDH1A1 973/4885 |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | DRD4 729/4885CYP11B2 536/4885ALDH1A1 858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.