Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205053 | 0.82 | TAS2R14 (0.49) | TAS2R14RAPGEF4FFAR4HTTLMNA | |
| SCHEMBL18355164 | 0.79 | TAS2R14 (0.44) | TAS2R14RAPGEF4FFAR4HTTLMNA | |
| SCHEMBL12541880 | 0.79 | POLB (0.54) | RAPGEF4FFAR4ALDH1A1POLBTDP1 | |
| SCHEMBL12883428 | 0.78 | TAS2R14 (0.47) | TAS2R14RAPGEF4FFAR4HTTLMNA | |
| SCHEMBL3529272 | 0.78 | SLC22A12 (0.49) | ALDH1A1POLBTDP1L3MBTL1CDK8 | |
| SCHEMBL14268240 | 0.77 | AR (0.50) | TAS2R14RAPGEF4FFAR4ALDH1A1TDP1 | |
| SCHEMBL1800248 | 0.77 | AR (0.50) | TAS2R14RAPGEF4ALDH1A1HTTLMNA | |
| SCHEMBL13951457 | 0.77 | KIF11 (0.50) | TAS2R14ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL28232084 | 0.77 | TAS2R14 (0.52) | TAS2R14ALDH1A1HTTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL18860171 | 0.76 | SLC22A12 (0.47) | ALDH1A1POLBTDP1L3MBTL1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313837-B1 | CARBOLINE ANTIPARASITICS | ZOETIS SERVICES LLC (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10570129-B2 | Carboline antiparasitics | ZOETIS SERVICES LLC (US) | 2020-02-25 | — | — | US | disclosed |
| US-20200031822-A1 | CARBOLINE ANTIPARASITICS | ZOETIS SERVICES LLC (US) | 2020-01-30 | — | — | US | disclosed |
| EP-3313837-A1 | CARBOLINE ANTIPARASITICS | Zoetis Services LLC (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016209635-A1 | CARBOLINE ANTIPARASITICS | ZOETIS SERVICES LLC (US) | 2016-12-29 | — | — | WO | disclosed |
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| CN-101765430-A | Novel pyrazole derivatives | HOFFMANN LA ROCHE | 2010-06-30 | — | — | CN | disclosed |
| EP-2182953-A2 | NEW PYRAZOL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
| WO-2009013211-A2 | NEW PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |
| US-3947513-A | FUNGICIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570129-B2 | Carboline antiparasitics | ADRA1D, DRD1, CHRM1 | TAS2R14 2350/4885RAPGEF4 3272/4885FFAR4 4146/4885 |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | TAS2R14 135/4885RAPGEF4 2525/4885FFAR4 511/4885 |
| US-20200031822-A1 | CARBOLINE ANTIPARASITICS | DRD1, ADRA1D, DRD2 | TAS2R14 2175/4885RAPGEF4 3791/4885FFAR4 4119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.