Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23605682 | 0.89 | MEN1 (0.49) | L3MBTL1CYP1A2PPARAABCB11CYP3A4 | |
| SCHEMBL21991884 | 0.86 | SSTR4 (0.48) | ALDH1A1L3MBTL1CYP1A2PPARAABCB11 | |
| SCHEMBL21991541 | 0.86 | PPARA (0.63) | ALDH1A1CYP1A2PPARAABCB11CYP3A4 | |
| SCHEMBL21991896 | 0.86 | ALDH1A1 (0.45) | ALDH1A1CYP1A2PPARAABCB11CYP3A4 | |
| SCHEMBL3881117 | 0.85 | DGAT1 (0.49) | ALDH1A1PPARAMAPTKDM4EMAPK1 | |
| SCHEMBL21991979 | 0.84 | PPARA (0.50) | ALDH1A1L3MBTL1CYP1A2PPARAABCB11 | |
| SCHEMBL21991304 | 0.83 | NPC1 (0.51) | ALDH1A1CYP1A2PPARAABCB11CYP3A4 | |
| SCHEMBL21991927 | 0.82 | PPARA (0.58) | ALDH1A1CYP1A2PPARAABCB11CYP3A4 | |
| SCHEMBL3798352 | 0.81 | KMT2A (0.50) | ALDH1A1L3MBTL1CYP1A2PPARAABCB11 | |
| SCHEMBL21991301 | 0.81 | CYP1A2 (0.41) | ALDH1A1CYP1A2PPARAABCB11CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220409566-A1 | CCL5 Inhibitors | LAPKO INC, dba AFECTA PHARMACEUTICALS | 2022-12-29 | — | — | US | disclosed |
| US-20220142961-A1 | CCL5 Inhibitors | LAPKO INC, dba AFECTA PHARMACEUTICALS | 2022-05-12 | — | — | US | disclosed |
| US-11318111-B2 | CCL5 inhibitors | LAPKO INC (US) | 2022-05-03 | — | — | US | disclosed |
| US-20210196665-A1 | CCL5 Inhibitors | AFECTA PHARMACEUTICALS, INC. (US) | 2021-07-01 | — | — | US | disclosed |
| US-10940132-B2 | CCL5 inhibitors | AFECTA PHARMACEUTICALS, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| US-20200138766-A1 | CCL5 INHIBITORS | LAPKO INC. DBA AFECTA PHARMACEUTICALS | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220142961-A1 | CCL5 Inhibitors | CCL5, CCL11, CCR5 | ALDH1A1 932/4885L3MBTL1 1170/4885CYP1A2 2919/4885 |
| US-20200138766-A1 | CCL5 INHIBITORS | CCL5, CCL11, CCR5 | ALDH1A1 932/4885L3MBTL1 1170/4885CYP1A2 2919/4885 |
| US-20210196665-A1 | CCL5 Inhibitors | CCL5, CCL11, CCR5 | ALDH1A1 932/4885L3MBTL1 1170/4885CYP1A2 2919/4885 |
| US-10940132-B2 | CCL5 inhibitors | CCL5, CCL11, CCR5 | ALDH1A1 932/4885L3MBTL1 1170/4885CYP1A2 2919/4885 |
| US-11318111-B2 | CCL5 inhibitors | CCL5, CCL11, CCR5 | ALDH1A1 932/4885L3MBTL1 1170/4885CYP1A2 2919/4885 |
| US-20220409566-A1 | CCL5 Inhibitors | CCL5, CCL11, CCR5 | ALDH1A1 932/4885L3MBTL1 1170/4885CYP1A2 2919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.