Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | GAA | P10253 | 7/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942207 | 0.84 | ALDH1A1 (0.64) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL940739 | 0.84 | ALDH1A1 (0.64) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL9656234 | 0.76 | POLB (0.69) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL9656226 | 0.76 | POLB (0.69) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL4259034 | 0.76 | ALDH1A1 (0.64) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL4259031 | 0.76 | ALDH1A1 (0.64) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL12443527 | 0.76 | ALDH1A1 (1.00) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL22056110 | 0.76 | RAB9A (0.60) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL13930637 | 0.76 | ALDH1A1 (0.64) | ALDH1A1GAATDP1POLBRAB9A | |
| SCHEMBL29883256 | 0.76 | RAB9A (0.60) | ALDH1A1GAATDP1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059160-A1 | Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof | TSINGHUA UNIVERSITY (CN) | 2025-02-20 | — | — | US | claimed |
| CN-115197126-A | Novel NMNAT enzyme agonist and preparation and application thereof | 清华大学 | 2022-10-18 | — | — | CN | claimed |
| WO-2020107221-A1 | CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF | TSINGHUA UNIVERSITY (CN) | 2020-06-04 | — | — | WO | claimed |
| US-20250059160-A1 | Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof | TSINGHUA UNIVERSITY (CN) | 2025-02-20 | — | — | US | disclosed |
| CN-115197126-A | Novel NMNAT enzyme agonist and preparation and application thereof | 清华大学 | 2022-10-18 | — | — | CN | disclosed |
| WO-2020107221-A1 | CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF | TSINGHUA UNIVERSITY (CN) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020107221-A1 | CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF | TSINGHUA UNIVERSITY (CN) | 2020-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059160-A1 | Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof | NAMPT, NNMT, NAPRT | ALDH1A1 1017/4885GAA 448/4885TDP1 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.