Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26828546 | 0.83 | EPHX2 (0.42) | EPHX2NR1H4GAAKDM4AL3MBTL1 | |
| SCHEMBL12231326 | 0.83 | GRM2 (0.43) | EPHX2NR1H4GAAKDM4AL3MBTL1 | |
| SCHEMBL19716620 | 0.82 | CA1 (0.50) | CA1CA2CA12GAAL3MBTL1 | |
| SCHEMBL24493194 | 0.82 | HDAC10 (0.42) | EPHX2NR1H4CA1CA2GAA | |
| SCHEMBL16935706 | 0.82 | GRM2 (0.43) | EPHX2NR1H4CA1CA2GAA | |
| SCHEMBL30898264 | 0.81 | GLS (0.49) | CA1CA2CA12GAAKDM4A | |
| SCHEMBL16785102 | 0.81 | GLS (0.49) | CA1CA2CA12GAAKDM4A | |
| SCHEMBL4894133 | 0.80 | NQO2 (0.49) | EPHX2NR1H4KDM4ANQO2 | |
| SCHEMBL20256516 | 0.79 | NQO2 (0.42) | CA1CA2CA12KDM4ACA9 | |
| SCHEMBL29924728 | 0.79 | GRM2 (0.49) | EPHX2NR1H4CA1CA2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807620-B2 | Quinazolinone compounds and related compounds | Plexium, Inc. (US) | 2023-11-07 | — | — | US | disclosed |
| EP-3886854-A1 | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | Nuvation Bio Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| US-11034669-B2 | Pyrrole and pyrazole compounds and methods of use thereof | NUVATION BIO INC. (BM) | 2021-06-15 | — | — | US | disclosed |
| US-11034669-B2 | Pyrrole and pyrazole compounds and methods of use thereof | NUVATION BIO INC. (BM) | 2021-06-15 | — | — | US | disclosed |
| US-20200239433-A1 | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2020-07-30 | — | — | US | disclosed |
| US-20200239433-A1 | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2020-07-30 | — | — | US | disclosed |
| WO-2020113094-A1 | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | NUVATION BIO INC. (US) | 2020-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239433-A1 | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | NCOA3, NCOA1, NR3C1 | EPHX2 3882/4885NR1H4 69/4885CA1 4265/4885 |
| US-11034669-B2 | Pyrrole and pyrazole compounds and methods of use thereof | NCOA3, NCOA1, NR3C1 | EPHX2 3882/4885NR1H4 69/4885CA1 4265/4885 |
| US-11807620-B2 | Quinazolinone compounds and related compounds | NQO2, COQ8A, PARK7 | EPHX2 4078/4885NR1H4 2685/4885CA1 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.