Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.54 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.54 |
| ▸ | FABP6 | P51161 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21333792 | 0.83 | FABP6 (0.50) | PARP1PARP10PARP11FABP6PDPK1 | |
| SCHEMBL20880758 | 0.80 | PARP1 (0.54) | PARP1PARP10PARP11FABP6PDPK1 | |
| SCHEMBL2985573 | 0.80 | PARP1 (0.54) | PARP1PARP10PARP11FABP6PDPK1 | |
| SCHEMBL2983974 | 0.80 | ALPL (0.46) | PARP1PARP10PARP11FABP6MAPT | |
| SCHEMBL4898912 | 0.75 | ALDH1A1 (0.44) | PARP1PARP10PARP11ADRA2AADRA2B | |
| SCHEMBL31170723 | 0.75 | ALDH1A1 (0.44) | PARP1PARP10PARP11ADRA2AADRA2B | |
| SCHEMBL21461173 | 0.75 | S100A4 (0.42) | PARP1PARP10PARP11FABP6PDPK1 | |
| SCHEMBL19744350 | 0.74 | MAPT (0.43) | PARP1PARP10PARP11ADRA2AADRA2B | |
| SCHEMBL31170819 | 0.74 | MAPT (0.43) | PARP1PARP10PARP11ADRA2AADRA2B | |
| SCHEMBL13801972 | 0.73 | FABP6 (0.43) | PARP1PARP10PARP11FABP6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200148634-A1 | ACLY INHIBITORS AND USES THEREOF | Nimbus Artemis, Inc. | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148634-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | PARP1 1809/4885PARP10 1023/4885PARP11 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.