Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14640349 | 0.87 | MAPT (0.42) | TP53HTTLMNAPSEN1PSEN2 | |
| SCHEMBL20365885 | 0.85 | TP53 (0.55) | TP53HTTLMNAPSEN1PSEN2 | |
| SCHEMBL19539103 | 0.84 | HTT (0.44) | TP53HTTLMNAALDH1A1TDP1 | |
| SCHEMBL24119872 | 0.83 | GAA (0.41) | TP53HTTLMNAPSEN1PSEN2 | |
| SCHEMBL22932512 | 0.83 | PSEN1 (0.37) | TP53HTTLMNAPSEN1PSEN2 | |
| SCHEMBL22028461 | 0.81 | ALDH1A1 (0.38) | HTTLMNAPSEN1PSEN2APH1B | |
| SCHEMBL29810173 | 0.81 | MEN1 (0.50) | TP53HTTLMNAALDH1A1TDP1 | |
| SCHEMBL574260 | 0.81 | MEN1 (0.50) | TP53HTTLMNAALDH1A1TDP1 | |
| SCHEMBL23031748 | 0.81 | TP53 (0.38) | TP53HTTLMNAPSEN1PSEN2 | |
| SCHEMBL21725496 | 0.80 | HTT (0.38) | TP53HTTLMNAPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220251076-A1 | Inhibitors of Beta-Hydoxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2022-08-11 | — | — | US | disclosed |
| US-20210032233-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2021-02-04 | — | — | US | disclosed |
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | TP53 3497/4885HTT 4501/4885LMNA 2463/4885 |
| US-20210032233-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | ASPH, CYP46A1, ALDH7A1 | TP53 873/4885HTT 1545/4885LMNA 2397/4885 |
| US-20220251076-A1 | Inhibitors of Beta-Hydoxylase for Treatment of Cancer | ASPH, HAGH, FAH | TP53 717/4885HTT 765/4885LMNA 2246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.