SCHEMBL22004780

SCHEMBL22004780

CN(C)c1c(Cl)cc(Br)cc1CCC=O

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PYCR1 P32322 1/20 0.31
CRHR1 P34998 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9955356 0.73 NMT1 (0.38) PYCR1CRHR1
SCHEMBL17713325 0.71 PYCR1 (0.41) PYCR1
SCHEMBL9502262 0.71 ALDH1A1 (0.35) PYCR1
SCHEMBL21041675 0.69 ALDH1A1 (0.31)
SCHEMBL637171 0.66 GABRA1 (0.36)
SCHEMBL8335195 0.65 ERN1 (0.48)
SCHEMBL14405277 0.65 SMN1; SMN2 (0.36)
SCHEMBL20116559 0.65 ALDH1A3 (0.36)
SCHEMBL28861293 0.64 HSP90AA1 (0.39)
SCHEMBL28155650 0.64 MEN1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3653618-A1 NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2020-05-20 EP disclosed