Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199949 | 0.92 | HDAC3 (0.42) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 | |
| SCHEMBL8171173 | 0.83 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 | |
| SCHEMBL8199952 | 0.81 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 | |
| SCHEMBL17671260 | 0.81 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 | |
| SCHEMBL21965833 | 0.80 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 | |
| SCHEMBL998165 | 0.80 | IDO1 (0.46) | P2RX1MAPTALDH1A1 | |
| SCHEMBL10988446 | 0.80 | ALDH1A1 (0.58) | MAPTALDH1A1GAATDP1RAB9A | |
| SCHEMBL5782136 | 0.80 | ALDH1A1 (0.58) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 | |
| SCHEMBL679095 | 0.80 | ALDH1A1 (0.50) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 | |
| SCHEMBL8168077 | 0.79 | DHFR (0.46) | HDAC3HDAC1HDAC2HDAC6TMPRSS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023036217-A1 | ACRYLAMIDE COMPOUND AND USE THEREOF | 南京明德新药研发有限公司 | 2023-03-16 | — | — | WO | disclosed |
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2182953-A2 | NEW PYRAZOL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
| WO-2009013211-A2 | NEW PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | HDAC3 276/4885HDAC1 519/4885HDAC2 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.