Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 1.00 |
| ▸ | GRM6 | O15303 | 2/20 | 1.00 |
| ▸ | GRM7 | Q14831 | 2/20 | 1.00 |
| ▸ | GRM4 | Q14833 | 2/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 1/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 1/20 | 1.00 |
| ▸ | GSR | P00390 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | GRIK1 | P39086 | 1/20 | 1.00 |
| ▸ | GRM5 | P41594 | 1/20 | 1.00 |
| ▸ | GRIA1 | P42261 | 1/20 | 1.00 |
| ▸ | GRIA2 | P42262 | 1/20 | 1.00 |
| ▸ | GRIA3 | P42263 | 1/20 | 1.00 |
| ▸ | SLC1A3 | P43003 | 1/20 | 1.00 |
| ▸ | SLC1A2 | P43004 | 1/20 | 1.00 |
| ▸ | SLC1A1 | P43005 | 1/20 | 1.00 |
| ▸ | GRIA4 | P48058 | 1/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 1/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 1/20 | 1.00 |
| ▸ | GRIK2 | Q13002 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL1554237 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL1332007 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL1332297 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL43222 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL2202 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL1332144 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL410241 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL5704264 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL1330917 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL931953 | 1.00 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230088127-A1 | ISOTOPES OF ALPHA KETOGLUTARATE AND RELATED COMPOUNDS AND THEIR USE IN HYPERPOLARIZED IMAGING | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2023-03-23 | — | — | US | disclosed |
| EP-4090648-A1 | ISOTOPES OF ALPHA KETOGLUTARATE AND RELATED COMPOUNDS AND THEIR USE IN HYPERPOLARIZED IMAGING | The Government of The United States of America as represented by The Secretary, Department of Health and Human Services (US) | 2022-11-23 | — | — | EP | disclosed |
| US-9673030-B2 | Computer readable storage mediums, methods and systems for normalizing chemical profiles in biological or medical samples detected by mass spectrometry | EMORY UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
| WO-2012006329-A2 | APOE4 AND APOJ BIOMARKER-BASED PREVENTION AND TREATMENT OF DEMENTIA | GENOMIND, LLC (US) | 2012-01-12 | — | — | WO | disclosed |
| US-20120009125-A1 | APOE4 AND APOJ BIOMARKER-BASED PREVENTION AND TREATMENT OF DEMENTIA | GENOMIND, LLC | 2012-01-12 | — | — | US | disclosed |
| US-20110282587-A1 | COMPUTER READABLE STORAGE MEDIUMS, METHODS AND SYSTEMS FOR NORMALIZING CHEMICAL PROFILES IN BIOLOGICAL OR MEDICAL SAMPLES DETECTED BY MASS SPECTROMETRY | EMORY UNIVERSITY (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230088127-A1 | ISOTOPES OF ALPHA KETOGLUTARATE AND RELATED COMPOUNDS AND THEIR USE IN HYPERPOLARIZED IMAGING | IDH1, SLC25A11, GCDH | GRM8 2379/4885GRM6 2378/4885GRM7 2406/4885 |
| US-20120009125-A1 | APOE4 AND APOJ BIOMARKER-BASED PREVENTION AND TREATMENT OF DEMENTIA | GSTK1, DNAJB11, GSTM1 | GRM8 107/4885GRM6 62/4885GRM7 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.