Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ADK | P55263 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521021 | 1.00 | HTR1A (0.48) | HTR1ASIGMAR1ADK | |
| SCHEMBL22605205 | 1.00 | HTR1A (0.48) | HTR1ASIGMAR1ADK | |
| SCHEMBL20521020 | 1.00 | HTR1A (0.48) | HTR1ASIGMAR1ADK | |
| SCHEMBL20521023 | 1.00 | HTR1A (0.48) | HTR1ASIGMAR1ADK | |
| SCHEMBL9041117 | 0.79 | HRH3 (0.58) | HTR1ASIGMAR1ADK | |
| SCHEMBL6211693 | 0.76 | ACHE (0.50) | SIGMAR1 | |
| SCHEMBL14063973 | 0.76 | SIGMAR1 (0.53) | SIGMAR1 | |
| SCHEMBL23850163 | 0.74 | ALDH1A1 (0.48) | — | |
| SCHEMBL23924608 | 0.73 | SIGMAR1 (0.52) | SIGMAR1 | |
| SCHEMBL23924607 | 0.73 | SIGMAR1 (0.52) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662203-B2 | Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection | HOFFMANN-LA ROCHE INC. (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662203-B2 | Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection | IDO1, IDO2, KYNU | HTR1A 145/4885SIGMAR1 983/4885ADK 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.