⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22014385 | 0.81 | FABP3 (0.32) | — | |
| SCHEMBL22014427 | 0.81 | GCGR (0.32) | — | |
| SCHEMBL9804429 | 0.77 | CA1 (0.35) | — | |
| SCHEMBL28799188 | 0.77 | GABRA1 (0.47) | — | |
| SCHEMBL28799190 | 0.75 | GABRA1 (0.35) | — | |
| SCHEMBL24784393 | 0.74 | GABRA1 (0.33) | — | |
| SCHEMBL25138979 | 0.73 | KDM4E (0.34) | — | |
| SCHEMBL8125391 | 0.72 | GABRA1 (0.54) | — | |
| SCHEMBL25841924 | 0.71 | SOAT2 (0.32) | — | |
| SCHEMBL25841974 | 0.70 | FABP3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |
| WO-2020102100-A9 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2022-01-06 | — | — | WO | disclosed |
| WO-2020102100-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |