SCHEMBL22011035

SCHEMBL22011035

CNCc1c(C)oc2c(Br)cccc12

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.37
CA2 P00918 1/20 0.36
ALDH1A1 P00352 1/20 0.33
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
TAAR1 Q96RJ0 1/20 0.32
NR1I3 Q14994 1/20 0.32
PRMT6 Q96LA8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21963707 0.81 CA2 (0.39) CA2ALDH1A1NR1I3PRMT6
SCHEMBL22010749 0.81 CA2 (0.39) LOXL2CA2MAOAMAOBNR1I3
SCHEMBL8038421 0.73 LOXL2 (0.40) LOXL2ALDH1A1MAOAMAOB
SCHEMBL24923421 0.73 LOXL2 (0.34) LOXL2
SCHEMBL1253476 0.73 CA2 (0.62) CA2ALDH1A1MAOANR1I3
SCHEMBL28879852 0.72 TAAR1 (0.43) LOXL2ALDH1A1TAAR1PRMT6
Hydrochloric Acid SCHEMBL21964032 0.71 CA2 (0.60) CA2ALDH1A1MAOANR1I3
SCHEMBL22010747 0.71 ESR1 (0.38) CA2NR1I3
SCHEMBL28604570 0.70 LOXL2 (0.38) LOXL2ALDH1A1MAOAMAOB
SCHEMBL31033279 0.70 MTNR1B (0.40) MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020099341-A1 ANTIBIOTIC COMPOUNDS, METHODS OF MANUFACTURING THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF DEBIOPHARM INTERNATIONAL S.A. (CH) 2020-05-22 WO disclosed