Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22011478 | 0.91 | ALDH1A1 (0.43) | HPGDGPR119EPHX1MEN1KMT2A | |
| SCHEMBL28604432 | 0.88 | ALDH1A1 (0.40) | HPGDGPR119EPHX1MEN1KMT2A | |
| SCHEMBL21964207 | 0.87 | L3MBTL1 (0.38) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21964206 | 0.86 | HPGD (0.47) | HPGDGPR119EPHX1MEN1KMT2A | |
| SCHEMBL15297469 | 0.85 | GPR119 (0.44) | HPGDGPR119EPHX1MEN1KMT2A | |
| SCHEMBL24220741 | 0.83 | ALDH1A1 (0.42) | HPGDGPR119MEN1KMT2AALDH1A1 | |
| SCHEMBL5195241 | 0.81 | EPHX1 (0.48) | HPGDGPR119EPHX1MEN1KMT2A | |
| SCHEMBL21964077 | 0.81 | L3MBTL1 (0.42) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL24220807 | 0.80 | MEN1 (0.43) | HPGDGPR119EPHX1MEN1KMT2A | |
| SCHEMBL28607247 | 0.80 | MEN1 (0.43) | HPGDGPR119EPHX1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227091-A | As AM2Heterocyclic spiro-compounds as receptor inhibitors | 谢菲尔德大学 | 2021-08-06 | — | — | CN | disclosed |