Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 16/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 15/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25797192 | 0.81 | PNMT (0.42) | PNMTASIC3PRMT5WDR77KDM4E | |
| SCHEMBL22012076 | 0.76 | ASIC3 (0.37) | ASIC3PRMT5WDR77 | |
| SCHEMBL22012078 | 0.74 | ASIC3 (0.34) | ASIC3PRMT5WDR77 | |
| SCHEMBL14330865 | 0.74 | PRMT5 (0.48) | PNMTPRMT5WDR77KDM4ECYP2C19 | |
| SCHEMBL21962432 | 0.73 | ALDH1A1 (0.51) | ASIC3PRMT5WDR77KDM4EALDH1A1 | |
| SCHEMBL1870797 | 0.72 | PNMT (0.46) | PNMTPRMT5WDR77 | |
| SCHEMBL16624079 | 0.71 | PNMT (0.42) | PNMTASIC3PRMT5WDR77KDM4E | |
| SCHEMBL22012770 | 0.71 | PRMT5 (0.37) | ASIC3PRMT5WDR77 | |
| SCHEMBL26032152 | 0.71 | PRMT5 (0.46) | ASIC3PRMT5WDR77 | |
| SCHEMBL22012077 | 0.70 | PRMT5 (0.34) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |