Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 19/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22012769 | 0.73 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL22012076 | 0.71 | ASIC3 (0.37) | PRMT5WDR77ASIC3 | |
| SCHEMBL22012071 | 0.71 | PNMT (0.38) | PRMT5WDR77ASIC3 | |
| SCHEMBL22012078 | 0.69 | ASIC3 (0.34) | PRMT5WDR77ASIC3 | |
| SCHEMBL21962438 | 0.65 | PRMT5 (0.32) | PRMT5WDR77ASIC3 | |
| SCHEMBL21962432 | 0.63 | ALDH1A1 (0.51) | PRMT5WDR77ASIC3 | |
| SCHEMBL30244016 | 0.63 | NLRP3 (0.39) | PRMT5WDR77 | |
| SCHEMBL29229884 | 0.59 | ADORA1 (0.62) | — | |
| SCHEMBL25975792 | 0.58 | CARM1 (0.56) | PRMT5WDR77 | |
| SCHEMBL10855362 | 0.58 | RAD52 (0.46) | PRMT5WDR77ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |