Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25032673 | 0.79 | LTA4H (0.41) | GRM2OPRK1TSHRLTA4HSMN1; SMN2 | |
| SCHEMBL22013020 | 0.79 | POLB (0.36) | TSHRALDH1A1LTA4HSMN1; SMN2POLB | |
| SCHEMBL30243895 | 0.78 | NLRP3 (0.42) | — | |
| SCHEMBL20692427 | 0.78 | NLRP3 (0.42) | — | |
| SCHEMBL30244284 | 0.78 | NLRP3 (0.42) | — | |
| SCHEMBL12639940 | 0.71 | PYCR1 (0.58) | ALDH1A1LTA4HSMN1; SMN2BCHEACHE | |
| SCHEMBL3151763 | 0.70 | LTA4H (0.47) | GRM2TSHRALDH1A1LTA4HSMN1; SMN2 | |
| SCHEMBL5034015 | 0.70 | SMN1; SMN2 (0.48) | ALDH1A1LTA4HSMN1; SMN2BCHEACHE | |
| SCHEMBL21962404 | 0.70 | NOS3 (0.41) | TSHRALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6441252 | 0.69 | ACHE (0.47) | GRM2SMN1; SMN2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |