Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962629 | 0.88 | DAO (0.40) | DAOPDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL22015042 | 0.87 | DAO (0.36) | DAOCNR2 | |
| SCHEMBL21962152 | 0.83 | DAO (0.36) | DAOPDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL20919052 | 0.74 | THRA (0.40) | L3MBTL1NPC1RAB9AEPHX1EPHX2 | |
| SCHEMBL22014946 | 0.73 | FFAR1 (0.40) | PLA2G2APDGFRBPDGFRA | |
| SCHEMBL22014729 | 0.70 | DAO (0.33) | DAOCNR2 | |
| SCHEMBL6761331 | 0.70 | CA2 (0.39) | PLA2G2A | |
| SCHEMBL20698837 | 0.70 | CA2 (0.34) | PLA2G2ATHRB | |
| SCHEMBL20698736 | 0.69 | NLRP3 (0.40) | — | |
| SCHEMBL25138891 | 0.66 | FABP3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |