Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475203 | 0.85 | NLRP3 (0.41) | NLRP3GAAFABP3FABP4EIF4A3 | |
| SCHEMBL19621872 | 0.84 | CA1 (0.46) | NLRP3GAASOAT2MYCSOAT1 | |
| SCHEMBL20698736 | 0.83 | NLRP3 (0.40) | NLRP3GCGRSOAT2MYCSOAT1 | |
| SCHEMBL20681156 | 0.83 | NLRP3 (0.40) | NLRP3GCGRSOAT2MYCSOAT1 | |
| SCHEMBL19475243 | 0.80 | MTNR1A (0.42) | NLRP3GAASOAT2MYCSOAT1 | |
| SCHEMBL25112052 | 0.79 | NLRP3 (0.38) | NLRP3GCGRSOAT2MYCSOAT1 | |
| SCHEMBL18309170 | 0.78 | THRB (0.43) | — | |
| SCHEMBL22015593 | 0.78 | NLRP3 (0.32) | NLRP3GAAGCGREIF4A3 | |
| SCHEMBL22014876 | 0.78 | POLB (0.39) | NLRP3GAASOAT2MYCSOAT1 | |
| SCHEMBL19508138 | 0.77 | NLRP3 (0.36) | NLRP3GCGRGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |