Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20698978 | 0.87 | ATM (0.41) | ATMSOAT2MYCSOAT1MAP2K3 | |
| SCHEMBL25139071 | 0.86 | L3MBTL1 (0.35) | POLBATMACACBSOAT2MYC | |
| SCHEMBL25139003 | 0.82 | GABRA1 (0.32) | POLBATMSOAT2MYCSOAT1 | |
| SCHEMBL25067030 | 0.80 | LMNA (0.33) | POLBATMACACBALDH1A1MEN1 | |
| SCHEMBL20681103 | 0.78 | ATM (0.37) | POLBATMMAPTTSHRTHRA | |
| SCHEMBL30791047 | 0.78 | ATM (0.37) | POLBATMMAPTTSHRTHRA | |
| SCHEMBL22014897 | 0.78 | NLRP3 (0.41) | POLBSOAT2MYCSOAT1MAP2K3 | |
| SCHEMBL19621872 | 0.77 | CA1 (0.46) | POLBSOAT2MYCSOAT1MAP2K3 | |
| SCHEMBL25138899 | 0.77 | L3MBTL1 (0.34) | ATMKCNJ5KCNJ3KDM4E | |
| SCHEMBL25139063 | 0.76 | SOAT2 (0.33) | SOAT2MYCSOAT1MAP2K3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658538-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-04-19 | — | — | EP | disclosed |
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |