Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475213 | 0.87 | EIF4A3 (0.36) | NLRP3EIF4A3GCGRGAA | |
| SCHEMBL20698765 | 0.86 | SIRT1 (0.35) | NLRP3EIF4A3GCGR | |
| SCHEMBL19507330 | 0.83 | MTNR1A (0.40) | NLRP3GAA | |
| SCHEMBL22014723 | 0.79 | GABRA1 (0.35) | EIF4A3 | |
| SCHEMBL23692140 | 0.79 | — | — | |
| SCHEMBL22014897 | 0.78 | NLRP3 (0.41) | NLRP3EIF4A3GCGRGAA | |
| SCHEMBL27110079 | 0.77 | CA1 (0.41) | — | |
| SCHEMBL19621872 | 0.73 | CA1 (0.46) | NLRP3GAA | |
| SCHEMBL15082628 | 0.70 | GABRA1 (0.31) | — | |
| SCHEMBL22014632 | 0.70 | MTNR1A (0.37) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |