Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.50 |
| ▸ | RAB9A | P51151 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576593 | 0.80 | DYRK1A (0.54) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6850684 | 0.78 | SLC6A2 (0.49) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL30661704 | 0.78 | SLC6A2 (0.49) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5912693 | 0.77 | NPC1 (0.50) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27736352 | 0.77 | ALDH1A1 (0.50) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL28211564 | 0.77 | SCN5A (0.49) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL21412311 | 0.77 | HDAC4 (0.40) | MAPTCYP1A2CYP2C19CYP19A1DHODH | |
| SCHEMBL30661712 | 0.76 | NPC1 (0.62) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL29105359 | 0.76 | NPC1 (0.62) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL3628069 | 0.75 | NPC1 (0.61) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624177-A | Fluorescent probe responding to nitrite peroxide and preparation method and application thereof | 上海交通大学 | 2024-03-01 | — | — | CN | disclosed |
| CN-112645885-B | Iminopyridazine derivative, preparation method and application thereof, and pesticide | 武汉工程大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-110093061-B | Photosensitive resin with maleimide structure and preparation method and application thereof | 浙江永太新材料有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-112645885-A | Iminopyridazine derivative, preparation method and application thereof, and pesticide | 武汉工程大学 | 2021-04-13 | — | — | CN | disclosed |
| CN-106061974-B | Maleimide derivatives as the conditioning agent of WNT approach | 新加坡科技研究局 | 2018-04-20 | — | — | CN | disclosed |
| US-8178540-B2 | Pyrimidylmethyl-sulfonamide compounds | BASF SE (DE) | 2012-05-15 | — | — | US | disclosed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-7888357-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2011-02-15 | — | — | US | disclosed |
| EP-2264014-A1 | Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors | Université Louis Pasteur (FR) | 2010-12-22 | — | — | EP | disclosed |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| US-20100077512-A1 | Pyridazin-4-ylmethyl-sulfonamides used as Fungicides and Against Arthropods | BASF SE (DE) | 2010-03-25 | — | — | US | disclosed |
| US-20100069243-A1 | Pyrimidylmethyl-Sulfonamide Compounds | BASF SE (DE) | 2010-03-18 | — | — | US | disclosed |
| US-20080132698-A1 | Use of N-oxide compounds in coupling reactions | UNIVERSITY OF OTTAWA | 2008-06-05 | — | — | US | disclosed |
| US-20080132698-A1 | Use of N-oxide compounds in coupling reactions | UNIVERSITY OF OTTAWA | 2008-06-05 | — | — | US | disclosed |
| US-20080132698-A1 | Use of N-oxide compounds in coupling reactions | UNIVERSITY OF OTTAWA | 2008-06-05 | — | — | US | disclosed |
| US-20060073472-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | UNIVERSITE DE STRASBOURG (FR) | 2006-04-06 | — | — | US | disclosed |
| EP-1430033-A4 | ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE | UNIV NORTHWESTERN (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1430033-A1 | ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE | NORTHWESTERN UNIVERSITY (US) | 2004-06-23 | — | — | EP | disclosed |
| US-20030176437-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-09-18 | — | — | US | disclosed |
| WO-2003018563-A1 | ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE | NORTHWESTERN UNIVERSITY (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069243-A1 | Pyrimidylmethyl-Sulfonamide Compounds | TPMT, NISCH, PPA1 | NPC1 4195/4885RAB9A 2914/4885MAPT 3912/4885 |
| US-20060073472-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | CASP2, CASP1, DAPK2 | NPC1 3563/4885RAB9A 3629/4885MAPT 1672/4885 |
| US-20080132698-A1 | Use of N-oxide compounds in coupling reactions | CYP4X1, CYP4F3, CYP1A2 | NPC1 731/4885RAB9A 1209/4885MAPT 4072/4885 |
| US-20100077512-A1 | Pyridazin-4-ylmethyl-sulfonamides used as Fungicides and Against Arthropods | PIR, PRDX4, PRDX2 | NPC1 4528/4885RAB9A 3677/4885MAPT 3435/4885 |
| US-20030176437-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | CASP2, CASP1, DAPK2 | NPC1 3563/4885RAB9A 3629/4885MAPT 1672/4885 |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | CASP2, CASP1, DAPK2 | NPC1 3563/4885RAB9A 3629/4885MAPT 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.