Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26047486 | 0.93 | HDAC8 (0.57) | HDAC8ALDH1A1HPGDHTTKDM4E | |
| SCHEMBL21957672 | 0.90 | HDAC8 (0.58) | HDAC8ALDH1A1KDM4EAPPMAOB | |
| SCHEMBL1884913 | 0.83 | CA12 (0.62) | HDAC8ABCG2MAPTCA12CA4 | |
| SCHEMBL1884911 | 0.83 | CA12 (0.62) | HDAC8ABCG2MAPTCA12CA4 | |
| SCHEMBL18559977 | 0.80 | HDAC8 (0.69) | HDAC8PTPN1ALDH1A1HTTKDM4E | |
| SCHEMBL21957648 | 0.79 | HDAC8 (0.54) | HDAC8MAOBMAPT | |
| SCHEMBL1745061 | 0.79 | HDAC8 (0.53) | HDAC8APPMAOBCA12CA4 | |
| SCHEMBL1745060 | 0.79 | HDAC8 (0.53) | HDAC8APPMAOBCA12CA4 | |
| SCHEMBL4262496 | 0.79 | ALDH1A1 (0.58) | HDAC8ALDH1A1KDM4EAPPGSK3B | |
| SCHEMBL4262500 | 0.79 | ALDH1A1 (0.58) | HDAC8ALDH1A1KDM4EAPPGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111184866-B | Combination treatment of bacterial infections | 香港中文大学 | 2023-12-19 | — | — | CN | disclosed |
| US-11690810-B2 | Combination treatment of bacterial infection | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2023-07-04 | — | — | US | disclosed |
| US-11690810-B2 | Combination treatment of bacterial infection | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2023-07-04 | — | — | US | disclosed |
| US-20200155641-A1 | COMBINATION TREATMENT OF BACTERIAL INFECTION | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155641-A1 | COMBINATION TREATMENT OF BACTERIAL INFECTION | PGC, NRDC, PYCARD | HDAC8 241/4885PTPN1 2611/4885ALDH1A1 3345/4885 |
| US-11690810-B2 | Combination treatment of bacterial infection | PGC, NRDC, PYCARD | HDAC8 241/4885PTPN1 2611/4885ALDH1A1 3345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.