Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PARG | Q86W56 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312051 | 0.85 | KDM4E (0.57) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL22017360 | 0.80 | KDM4E (0.43) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL22016212 | 0.79 | PARG (0.50) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL13376862 | 0.77 | PGR (0.64) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL5167218 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL13681196 | 0.70 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2268296 | 0.70 | ALDH1A1 (0.77) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL22114903 | 0.68 | GPR3 (0.59) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL21957305 | 0.68 | AR (0.54) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL22016560 | 0.67 | AR (0.40) | ALDH1A1KDM4EHSD17B10HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | ALDH1A1 838/4885KDM4E 1390/4885HSD17B10 3422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.