Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 7/20 | 0.33 |
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 6/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.33 |
| ▸ | HTT | P42858 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22016487 | 0.69 | TSHR (0.35) | MEN1KMT2AHTTTSHR | |
| SCHEMBL22016174 | 0.67 | PLK1 (0.34) | KMT2ARXFP1 | |
| SCHEMBL22016209 | 0.67 | ALDH1A1 (0.35) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL11711827 | 0.65 | MEN1 (1.00) | MEN1KMT2ALMNAHTTALDH1A1 | |
| SCHEMBL24312044 | 0.64 | RXFP1 (0.33) | KMT2AKDM4ERXFP1 | |
| SCHEMBL22016171 | 0.64 | KDM4E (0.38) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL9570042 | 0.63 | RAB9A (0.43) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL11717674 | 0.63 | KMT2A (0.83) | MEN1KMT2ALMNAHTTNPSR1 | |
| SCHEMBL9570306 | 0.62 | AGTR1 (0.39) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL1989662 | 0.60 | MEN1 (0.40) | MEN1KMT2AALDH1A1GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | MEN1 2786/4885KMT2A 2755/4885ADRA1A 768/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | MEN1 2786/4885KMT2A 2755/4885ADRA1A 768/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | MEN1 2786/4885KMT2A 2755/4885ADRA1A 768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.