SCHEMBL22018387

SCHEMBL22018387

CCC(CC)n1c(=O)c2ccc3c4ccccc4oc4c(C#Cc5cccc(N)c5)cc(c1=O)c2c43

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
ADRB2 P07550 1/20 0.46
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
NPC1 O15118 2/20 0.36
HCRTR1 O43613 1/20 0.36
TNNI3 P19429 1/20 0.34
TNNT2 P45379 1/20 0.34
TNNC1 P63316 1/20 0.34
CDC14B O60729 1/20 0.32
CDC14A Q9UNH5 1/20 0.32
KDM4E B2RXH2 2/20 0.31
ALDH1A1 P00352 2/20 0.31
HPGD P15428 2/20 0.31
MAPT P10636 1/20 0.31
GAA P10253 1/20 0.30
HSD17B10 Q99714 1/20 0.30
PIK3CA P42336 1/20 0.30
MTOR P42345 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22018384 0.91 MEN1 (0.44) RAB9AL3MBTL1ADRB2MEN1KMT2A
SCHEMBL22018212 0.85 ALDH1A1 (0.31) RAB9ANPC1ALDH1A1SMN1; SMN2
SCHEMBL22018366 0.84 RAB9A (0.41) RAB9AL3MBTL1ADRB2MEN1KMT2A
SCHEMBL22018214 0.84 NPC1 (0.30) RAB9ANPC1SMN1; SMN2
SCHEMBL22018388 0.83 NPC1 (0.32) RAB9AL3MBTL1MEN1KMT2ANPC1
SCHEMBL22018386 0.80 HCRTR1 (0.36) RAB9AL3MBTL1ADRB2MEN1KMT2A
SCHEMBL22018367 0.75 MEN1 (0.40) RAB9AL3MBTL1ADRB2MEN1KMT2A
SCHEMBL22018211 0.71 MEN1 (0.37) RAB9AL3MBTL1MEN1KMT2ANPC1
SCHEMBL22019249 0.69 KDM4E (0.33) RAB9AMEN1KMT2ANPC1KDM4E
SCHEMBL22018210 0.67 MEN1 (0.31) MEN1KMT2AKDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020099793-A1 NOVEL BENZOTHIOXANTHENE P-CONJUGATED MOLECULES FOR ENERGY STORAGE UNIVERSITE D'ANGERS (FR) 2020-05-22 WO disclosed