Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 9/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14881615 | 0.80 | PLAT (0.53) | PLATADORA3ALDH1A1MAPTNPC1 | |
| SCHEMBL23013790 | 0.78 | PLAT (0.43) | PLATADORA3ALDH1A1SPRMAPT | |
| SCHEMBL15307002 | 0.78 | KMT2A (0.46) | PLATADORA3ALDH1A1MAPTNPC1 | |
| SCHEMBL20694710 | 0.76 | TRPM8 (0.45) | TRPM8ALDH1A1MAPTPDK1PDK2 | |
| SCHEMBL24833959 | 0.75 | PLAT (0.41) | PLATADORA3ALDH1A1MAPTNPC1 | |
| SCHEMBL404918 | 0.68 | PLAT (0.53) | PLATALDH1A1MAPTNPC1LMNA | |
| SCHEMBL28516116 | 0.68 | ALDH1A1 (0.49) | ALDH1A1MAPTNPC1LMNARAB9A | |
| SCHEMBL14881835 | 0.65 | MAPT (0.42) | PLATADORA3ALDH1A1SPRMAPT | |
| SCHEMBL24274526 | 0.65 | ADORA3 (0.46) | PLATADORA3ALDH1A1SPRMAPT | |
| SCHEMBL17820828 | 0.65 | PLAT (0.36) | PLATNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658148-B1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | TURNING POINT THERAPEUTICS INC (US) | 2024-07-10 | — | — | EP | disclosed |
| US-11155563-B2 | Macrocyclic compounds and uses thereof | Turning Point Therapeutics, Inc. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20210214373-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | Turning Point Therapeutics, Inc. | 2021-07-15 | — | — | US | disclosed |
| US-20200157119-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | Turning Point Therapeutics, Inc. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155563-B2 | Macrocyclic compounds and uses thereof | CSF3R, CSF1R, FLT3 | PLAT 2612/4885TRPM8 2529/4885ADORA3 2244/4885 |
| US-20200157119-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | CSF3R, CSF1R, FLT3 | PLAT 2612/4885TRPM8 2529/4885ADORA3 2244/4885 |
| US-20210214373-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | CSF3R, CSF1R, FLT3 | PLAT 2612/4885TRPM8 2529/4885ADORA3 2244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.