Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019559 | 1.00 | TSHR (0.42) | TSHRRECQLFAAHKMT2AMEN1 | |
| SCHEMBL17570951 | 0.86 | FAAH (0.50) | TSHRRECQLFAAHKMT2AMEN1 | |
| SCHEMBL17570970 | 0.86 | FAAH (0.50) | TSHRRECQLFAAHKMT2AMEN1 | |
| SCHEMBL22018660 | 0.84 | FAAH (0.56) | FAAHKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL22018659 | 0.83 | FAAH (0.39) | FAAHKMT2AMEN1MAPK1 | |
| SCHEMBL22047456 | 0.83 | FAAH (0.39) | FAAHKMT2AMEN1MAPK1 | |
| SCHEMBL21418148 | 0.81 | TSHR (0.42) | TSHRRECQLFAAHKMT2AMEN1 | |
| SCHEMBL17570956 | 0.80 | RECQL (0.39) | TSHRRECQLKMT2AREN | |
| SCHEMBL17616958 | 0.80 | RECQL (0.39) | TSHRRECQLKMT2AREN | |
| SCHEMBL30946962 | 0.77 | TSHR (0.42) | TSHRRECQLKMT2AMEN1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230114-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2021-07-29 | — | — | US | disclosed |
| US-10913713-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200172481-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2020-06-04 | — | — | US | disclosed |
| WO-2020102053-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230114-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | GABRA3, GABRA5, GABRA6 | TSHR 654/4885RECQL 4241/4885FAAH 2024/4885 |
| US-10913713-B2 | Methods of preparing cytotoxic benzodiazepine derivatives | GABRA3, GABRA5, GABRA6 | TSHR 654/4885RECQL 4241/4885FAAH 2024/4885 |
| US-20200172481-A1 | METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | GABRA3, GABRA5, GABRA6 | TSHR 654/4885RECQL 4241/4885FAAH 2024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.