Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL872596 | 0.83 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2RECQLUSP2GAA | |
| SCHEMBL20803847 | 0.78 | HRH3 (0.32) | ALDH1A1SMN1; SMN2KDM4ESIGMAR1MEN1 | |
| SCHEMBL10080570 | 0.78 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2RECQLUSP2GAA | |
| SCHEMBL21943642 | 0.77 | HTT (0.36) | ALDH1A1RECQLKDM4EMGLL | |
| SCHEMBL1708968 | 0.76 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2RECQLUSP2GAA | |
| SCHEMBL179555 | 0.75 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2RECQLUSP2GAA | |
| SCHEMBL8261443 | 0.75 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2RECQLUSP2GAA | |
| SCHEMBL10153213 | 0.73 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2RECQLUSP2GAA | |
| SCHEMBL18116866 | 0.72 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2RECQLUSP2GAA | |
| SCHEMBL19407841 | 0.72 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2RECQLUSP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106302-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-04-07 | — | — | US | disclosed |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | RNASE1, RNASEH1, RNASEL | ALDH1A1 1745/4885SMN1; SMN2 161/4885RECQL 393/4885 |
| US-20220106302-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | CYP3A4, SHH, GLI1 | ALDH1A1 428/4885SMN1; SMN2 4857/4885RECQL 4655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.