Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CD69 | Q07108 | 1/20 | 0.50 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.47 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.47 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20340748 | 0.91 | ALDH1A1 (0.60) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL24282018 | 0.90 | MAPK1 (0.60) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL19477041 | 0.88 | ALDH1A1 (0.57) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL19477852 | 0.88 | ALDH1A1 (0.57) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL24239885 | 0.88 | ALDH1A1 (0.62) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL24004417 | 0.88 | ALDH1A1 (0.62) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL24239542 | 0.88 | ALDH1A1 (0.62) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL20713635 | 0.88 | ALDH1A1 (0.62) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL22021019 | 0.88 | ALDH1A1 (0.62) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 | |
| SCHEMBL24004407 | 0.88 | ALDH1A1 (0.62) | ALDH1A1THRBMAPK1SMN1; SMN2CD69 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210228615-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2021-07-29 | — | — | US | disclosed |
| US-20200190515-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2020-06-18 | — | — | US | disclosed |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190515-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | RNASE1, RNASEH1, RNASEL | ALDH1A1 3065/4885THRB 4436/4885MAPK1 4496/4885 |
| US-20210228615-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | SMN1; SMN2, RBM17, RBM22 | ALDH1A1 2965/4885THRB 4657/4885MAPK1 4806/4885 |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | RNASE1, RNASEH1, RNASEL | ALDH1A1 1745/4885THRB 4154/4885MAPK1 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.